The ameliorative effect of dates phoenix dactylifera l. Amelioration of severe tnbs induced colitis by novel ap1 and. However, afterintravenous pretreatment with an antagonist of atpsensitive potassium channels glibenclamide, the ulcer lesions were increased. Rats with acetic acid induced colitis were treated by intraperitoneal or intrarectal administration of nacetylcysteine 500 mg kg treated group. Effect of ethanolic extract of coconut cocos nucifera on aspirininduced gastric ulcer in albino rats. Omeprazole and misoprostol for preventing gastric mucosa. A preliminary study of the antiinflammatory and anti. Atypical fractures of the femur and bisphosphonate therapy. Misoprostil enprostil 2 neutralization of gastric acid a systemic. The anti ulcer activity of hydro alcoholic extract of rhus coriaria linn. The rats were allowed access to feed and water ad libitum for 48 h and observed for signs of toxicity and death. Peptic ulcer, medicines, prostaglandins, gastrointestinal protection, gastrointestinal toxicity for more than a century, peptic ulcer disease has been a major cause of morbidity and mortality.
Gastroprotective effect of zingerone on ethanolinduced. The aqueous extract of chamomile and liqurice and chamomile oil exhibited significant p ulcer activity in this ulcer induced models compared with omeprazole as standard drug. Gastric ulcers were induced by ethanol 96%, 5 mlkg, po in male wistar rats and zingerone 50, 100, and 200 mgkg. Chronic wound healing in the skin nih guide, volume 22, number 29, august, 1993 rfa. Fruit pulp extract on indomethacininduced gastric ulcer in albino. Orally, after 45 min of methanolic extract and omeprazole treatment. Antiulcer activity of centella asiatica leaf extract against ethanolinduced gastric mucosal injury in rats. The first experiment established an additional effect of no, that gtn can help. The acetone extract of cucumis sativus seed reduces the paw edema induced by carrageenan by 43. It is known that nitroglycerin gtn can be converted to form a nitric oxide no molecule which is a highly reactive and unstable free radical species. The goal for patients taking opioids is to have a bm at least every 23 days. Finally, the same positive effect of the oral administration of camel milk was observed in rats with naproxeninduced peptic ulcers. Gastric ulcer was induced in rats and the ulcer size, mucosal epithelial cell proliferation of the ulcer margin, expression of growth factors epidermal growth factor egf, basic fibroblast.
Drink 8 glasses of fluid per day if able include fiber in the diet. The rats were fasted for 24 hours before the oral gavage pretreatment food but not water. The gastric ulcers were induced in rats by administrating absolute ethanol 90% 1ml200g. Idogun antiulcer herbal mixture is a potent antiulcer drug. Peptic ulcers are gastrointestinal lesions that occur in the stomach and duodenum as a result of ethanol consumption, helicobacter pylori infection and use of non steroidal antiinflammatory drugs. Ghrelin protects against ethanolinduced gastric ulcers in. Antiulcerogenic activity of scutia buxifolia on gastric. Acute lung injury, antihistamine, ards, methylprednisolone, pulmonary edema acute respiratory distress syndrome ards is a common devastating clinical syndrome of acute lung injury with high mortality rate, 26 to 58%1,2. Gastroprotective effect of vanillin on indomethacininduced gastric. Duodenal ulcer is the ulcer that occurs in the first part of the intestine. No is known to have many beneficial effects such as relaxing blood vessels, promoting digestive activity, and regulating blood pressure.
Nursing care plan a client with peptic ulcer disease the client with cancer of the stomach worldwide, cancer of the stomach is the most common cancer other than skin cancer. The gastric ulcers were induced in rats of either sex weighing between 150 g by administrating absolute ethanol 8 mlkg. The ulcer is the open sore in the lining of the stomach or intestine, similar to mouth ulcers stomatitis and skin ulcer. Antiulcerogenic effects of a hydroethanol 70% extract from stem bark of terminalia superba engl et diels combretaceae in rats and phytochemical screening free download as pdf file. A predictable b uncontrollable c lowintensity d repeated page 1158 515.
Quality of publications the main characteristics of the case reportsseries and the quality score derived from the ispeisop guidelines are shown in table 1. Perhaps at the highest dose consumed in this study 4. Pdf gastroprotective effect of zingerone on ethanol. Therefore, omeprazol is the choice for ulcer treatment along with the nsaids, taking as basis its efficiency, tolerance and safety20mg ideal dosage once a day 31,32. Effect of garlic oil on ethanol induced gastric ulcers in rats. Tongue ulcer in a female f344n rat from a chronic study. The possible involvement of garlic oil in restraining the oxidation process produced in gastric tissue was also investigated. In these methods thermal and clampingcortisone ulcers seem to be valuable tools in investigation of the healing process of gastric ulcer, because of the relatively long period of its persistence and closer histologic resemblance to human peptic ulcer. These results suggested a possible benefit of milk supplementation in treating peptic ulcer. Idogun on the stomach of ulcer induced albino rats. Pdf antiulcer activity of centella asiatica leaf extract. Effect of liqurice and chamomile extracts in the management.
Gastric juice, gastric mucosa, morphologies of gastric ulcers and protein expressions of both. Agricultural sciences correction for an inhibitor persistently decreased enteric methane emission from dairy cows with no negative effect on milk production, by alexander n. The patient should not have hard stools or straining. Therapeutic value of camel milk as antiulcerogenic effect. Omeprazole 20 mgkg were used as a standard drug for this study. The present study was performed to evaluate the antiulcerogenic activity of ethanol extract of centella asiatica against ethanolinduced gastric mucosal injury in rats.
Peptic ulcers are gastrointestinal lesions that occur in the stomach and duodenum as a result of ethanol consumption, helicobacter pylori infection and use of nonsteroidal antiinflammatory drugs. Research has indicated that rats become more vulnerable to. Beneficial effects of nacetylcysteine on acetic acid. Subcutaneous ghrelin administration 80 micro gkg reduced ulcer depth only.
The number of ulcers was counted by using the magnifying glass. Antiulcerogenic effect of camel milk against ethanol induced. Rats were administered intrarectal saline control group or acetic acid colitis model group. Antiulcerogenic effect of camel milk against ethanol. Protective role of phoenix dactylifera fruit against ethanol induced gastric ulcer in wistar rats background. National institute of arthritis and musculoskeletal and skin diseases national institute on aging national institute of child health and human development national institute of diabetes and digestive and kidney. Tongue ulcer gallery tongue ulcer in a female f344n rat from a chronic study. Evaluation of the antiulcer effect of aerva javanica. Central ghrelin 44,000 ngrat dosedependently reduced ethanol induced gastric ulcers by 3977%. Balakrishnan1 school of biomedicine 1, asia metropolitan university, g8, jalan kemacahaya 11, batu 9, 43200 cheras, selangor, malaysia. Each group containing five rats of either sex were orally treated respectively with distilled water ulcer control group, omeprazole 20mgkg reference group and 100, 200, 400 and 800mgkg extract of idogun anti ulcer mixture. Omeprazole lansoprazole pantoprazole rabeprazole c anti cholinergics. Evaluation of antiulcer activity of methanolic extract of. Nitroglycerin relieves emotional stressinduced stomach.
The incidence of gastric cancer is highest in hispanics,africanameri. Druginduced peptic ulcer disease clinical pharmacist, st lukes hospital, guardamangia, malta email. Various antibiotics are used to eradicate the bacteria that are responsible for the development of peptic ulcer disease pud. Clopidogrel delays gastric ulcer healing in rats request pdf. Effect of cardiospermum halicacabum on ethanolinduced. The leading product in the market, nurofen plus, contains 200 mg ibuprofen and 12.
This study was performed to determine the antiulcer effects of ethanol extract of parkia speciosa on indomethacin induced peptic ulcer in albino rats. The aqueous extract of chamomile and liqurice and chamomile oil exhibited significant p pdf only article. The incidence of peptic ulcer is increased due to stress, smoking, alcohol, helicobacter pylori and ingestion of nonsteroidal antiinflammatory drugs nsaid 3, 4, 5. Effect of garlic oil on ethanol induced gastric ulcers in. Differential reduction in preference for ethanol and ethanolpaired. Santha maria1, surya devarakonda 1, ajay kumar tv 2 and n. Gastric ulcer is one of the major gastrointestinal disorders, which occurs due to an imbalance between the offensive gastric acid secretion and defensive gastric mucosal integrity factors1, 2. Gastroprotective effect of vanillin on indomethacininduced gastric ulcer in rats. Low ethanolconsuming and medium ethanolconsuming rats developed a similar incidence of these lesions, while high ethanolconsuming rats showed the lowest incidence of intestinal ulcer. Reactive oxygen species are involved in the pathogenesis of these ulcers. Finally, the same positive effect of the oral administration of camel milk was observed in rats with naproxen induced peptic ulcers.
Accelerated ulcer healing and resistance to ulcer recurrence. Rats were divided into six groups with three rats in each group. In addition, the composition of cesb was clarified by highperformance liquid chromatography hplc. Gastroprotective effect of zingerone on ethanol induced gastric ulcers in rats article pdf available in medicina kaunas, lithuania 553. The assessment was carried out by using ulcer index, ulcer score and histopathological studies of the specimens. These features were absent in the ulcer induced rats that were subsequently treated with the idogun mixture. Oral administration of camel milk in rats with ethanolinduced gastric ulcer. Evaluation of the antiulcer effect of aerva javanica aerial. Antiulcerogenic effect of cuphea ignea extract against ethanol.
The antiulcer activity of hydro alcoholic extract of rhus coriaria linn. The fruit pulp was extracted with ethanol and the antiulcer activity of the extract in indomethacininduced gastric ulceration in swiss albino rats was. Ironically, nicorandil was found to be involved in the induction of oral ulcers in 1997 by reichert et al. Protective role of phoenix dactylifera fruit against. Classification of antiulcer drugs rtt functional group. Hyp1, a novel diamide compound, relieves inflammatory and. Thus, in an experimental model of gastritis induced by iodoacetamide, souza et al observed that, after the administration of aspirin 50 or 100 mgkg, the levels of lxa 4 in gastric mucosa of rats with gastritis were significantly higher than in healthy rats.
Gastric ulcers were induced in sprague dawley rats using one oral dose of. Rats of female sex weighing between 150 g 200 g were used. Benzohydrazide in hclethanolinduced gastric international. Research paper ulcer prevention effect of 3,4,5tihydroxyn0. Thus, the aim of this study was to assess the antioxidant abilities of oleuropein in comparison with ranitidine in ethanol induced gastric damages via evaluation of ulcer index inhibition, antioxidant enzyme activities, and lipid peroxidation level. Protective role of phoenix dactylifera fruit against ethanolinduced gastric ulcer in wistar rats background.
Ibuprofencodeine preparations first entered the australian overthecounter otc market in october 2002. Purified oleuropein from olive leaf extract has been shown to have antioxidant effects in our recent studies. Gastric ir injury was induced according to wada et al. Rats were killed after 1 h of ethanol exposure, and the incidence and severity of the ulceration were estimated, as well as the concentrations of gastrin in plasma, and histamine and mucus in the. This study was performed to determine the anti ulcer effects of ethanol extract of parkia speciosa on indomethacin induced peptic ulcer in albino rats. Gastric ulcers were induced by ethanol 96%, 5 mlkg, po in male wistar rats and zingerone 50, 100, and 200 mgkg was administrated orally. The response beginning ranitidine covers the ulcer describes the action of sucralfate carafate.
Cassia sigueana, ethanol, antiulcer, preventive index, gastric ulcer, histopathology introduction peptic ulcer is a chronic, nonmalignant inflammatory disease characterised by ulceration in the upper gastrointestinal tract stomach and duodenum where parietal cells are found. The use of sucralfate carafate along with antibiotics is the best combination therapy for peptic ulcer disease pud. Each was orally treated respectively with distilled water ulcer control group, omeprazole 20mgkg reference group and 100, 200, 400 and 800mgkg extract from idogun antiulcer. The ulcer index, lipid peroxidation and antioxidant enzyme activity gpx, catalase, sod were determined. A portion of the keratinized squamous epithelium of the tongue has been lost, exposing the underlying lamina propria. Normal saline and ranitidine were used as negative and positive control. Protective role of phoenix dactylifera fruit against ethanol. Research paper ulcer prevention effect of 3,4,5tihydroxy. Tongue ulcer in a female f344n rat from a chronic study higher magnification of figure 1. Gastroprotective effect of zingerone on ethanolinduced gastric. On the last day of treatment, rats were fasted for 24 h, and were then given ethanol, 80% 1 mlrat by gastric intubation to induce gastric ulcer. Garlic oil was evaluated for gastroprotective activity against ethanol induced ulcers. Effect of aspirin treatment on the prevention of esophageal. This study is aimed to evaluate the effect of zingerone on ethanol induced gastric ulcers in rats.
Conventional histology and immunohistochemistry for ghrelin, gastrin, and somatostatin were performed on gastric specimens from representative rats. Pirenzapine propantheline oxyphenonium d prostaglandin analogues. Water supplement had been removed two hours before oral pretreatment started. Gastric ulcer is the ulcer which occurs in the stomach. The effect of oral administration of raw camel milk 5 mlkg b. Oleuropein prevents ethanolinduced gastric ulcers via.
Antiulcer activities of liquorice and its derivatives in experimental gastric lesion induced by ibuprofen in rats. Hpna managing opioid induced constipation teaching sheet. They were kept in specially constructed cages to prevent coprophagia during and after the experiment. Quality of ulcer healing qouh is defined as ideal ulcer healing featuring with the fine granular ulcer scar, high functional restoration and the resistance to recurrence.
In this study, the preventive effects of the crude extract of scutia buxifolia cesb against gastric ulcer induced by 70% ethanol were evaluated in male wistar rats. Evaluation of antiulcer activity of hydro alcoholic extract. Evaluation of antiulcer activity of hydro alcoholic. The first page of the pdf of this article appears above. B inhibitors, namely, dtcmg and dhmeq, were investigated in male wistar rats with severe colitis, induced by tnbs. Antiulcerogenic effects of a hydroethanol 70% extract. Thus, the aim of this study was to assess the antioxidant abilities of oleuropein in comparison with ranitidine in ethanolinduced gastric damages via evaluation of ulcer index inhibition, antioxidant enzyme activities, and lipid peroxidation level. Antiulcer activity of centella asiatica leaf extract against ethanolinduced gastric mucosal injury in rats article pdf available in journal of medicinal plant research 4 july 2010 with. Mild tissue edema and presence of inflammatory cells were observed in the omeprazole treated section. Central ghrelin 44,000 ngrat dosedependently reduced ethanolinduced gastric ulcers by 3977%. The first experiment established an additional effect of no, that gtn can help prevent emotionally induced. The results obtained indicate that the acetone extract has significant antiinflammatory activity in rats. Omeprazole 20 mgkg were used as a standard drug for.
The protective effect of liquorice components and their derivatives against gastric ulcer induced by aspirin in rats. Cimetidine ranitidine pantaprazole b proton pump inhibitors. Effect of ethanolic extract of coconut cocos nucifera on aspirin. This study was designed to compare the rates of qouh achievement in rat gastric ulcer model between acid suppressant treated group and gastroprotectant treated group. A family member of a 28yearold patient who has suffered massive abdominal trauma in an automobile accident asks the nurse why the patient is receiving famotidine pepcid. Biochanin a gastroprotective effects in ethanolinduced. Braden scale for predicting pressure ulcer risk is a widely used standardized risk assessment tool. All rats were sacrificed after one additional hour. Pheniramine maleate attenuates oleic acidinduced acute.
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